{"id":9798,"date":"2022-04-28T09:11:08","date_gmt":"2022-04-28T07:11:08","guid":{"rendered":"https:\/\/www.ims-chips.com\/?p=9798"},"modified":"2022-04-28T12:37:08","modified_gmt":"2022-04-28T10:37:08","slug":"panamea-2","status":"publish","type":"post","link":"https:\/\/www.ims-chips.com\/?p=9798","title":{"rendered":"PanaMEA \u2013 ASIC for a Miniature Pancreatic Implant"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"9798\" class=\"elementor elementor-9798\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b95f7b4 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"b95f7b4\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6a450ae exad-glass-effect-no exad-sticky-section-no\" data-id=\"6a450ae\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2965045 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"2965045\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h6 class=\"elementor-heading-title elementor-size-default\">Newsletter 1\/2022<\/h6>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ec89295 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"ec89295\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-be7b58f exad-glass-effect-no exad-sticky-section-no\" data-id=\"be7b58f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cc1278c exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-heading\" data-id=\"cc1278c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">PanaMEA - ASIC for a Miniature Pancreatic Implant<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7cf53d0 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"7cf53d0\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-84dbef5 exad-glass-effect-no exad-sticky-section-no\" data-id=\"84dbef5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3dbecfc exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"3dbecfc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Front-end signal processing of Beta-cell electrical activities captured by a Micro-Electrode Array (MEA)<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-4a61be5 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"4a61be5\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7853281 exad-glass-effect-no exad-sticky-section-no\" data-id=\"7853281\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a69c041 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-image\" data-id=\"a69c041\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"750\" height=\"215\" src=\"https:\/\/www.ims-chips.com\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF-1024x294.jpg\" class=\"attachment-large size-large wp-image-9803\" alt=\"PanaMEA \u2013 ASIC for a Miniature Pancreatic Implant\" srcset=\"https:\/\/www.ims-chips.com\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF-1024x294.jpg 1024w, https:\/\/www.ims-chips.com\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF-300x86.jpg 300w, https:\/\/www.ims-chips.com\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF-768x220.jpg 768w, https:\/\/www.ims-chips.com\/wp-content\/uploads\/2022\/04\/IMS_Newsletter_01_22_de_NF.jpg 1385w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e303399 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"e303399\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><em>Front-end beta-cell signal processing scheme<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-8177dde elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"8177dde\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-561822e exad-glass-effect-no exad-sticky-section-no\" data-id=\"561822e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-769e222 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"769e222\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\n<p>There are millions of people worldwide suffering\nfrom type 2 diabetes mellitus, which is\ncaused by the body\u2019s ineffective use of insulin.\nThe insulin is generated in the beta-cells\nin the pancreas. There is a direct relationship\nbetween the beta-cell\u2019s electrical activity\nin the form of membrane oscillatory bursts\nand extracellular glucose concentration. In\nthe BMBF project \u201cPanaMEA\u201d (Pankreas-\nImplantat auf MEA-Basis, grant number\n13GW0397), a miniaturized pancreatic\nimplant is being developed that measures this\nelectrical activity.<\/p>\n<p>The main task for IMS CHIPS is to develop a\nlow-power front-end ASIC to do signal processing\nof the beta-cell signals captured by\na microelectrode array (MEA). A bio-marker,\nthe so-called Fraction of Plateau Phase\n(FOPP), is defined for the beta-cell signal.\nIt is the percentage of time with beta-cell\nactivity. A high FOPP corresponds to a high\nglucose level. In conventional beta-cell monitoring\nmethods, all signal details, including\nFOPP-irrelevant high frequency contents are\nrecorded, and the FOPP value is calculated\nby postprocessing this signal. This will lead to\na big data volume and results in a system with\nhigh-power consumption for data transmission\nand processing. Instead of recording all\nthe signal details, we have used a very simple\ncircuit structure, i.e., a differential envelope\ndetector with diodes and capacitors, to filter\nout the high frequency contents and obtain\nthe FOPP-relevant information. The design\noverhead is kept to a minimum and the data\nvolume is highly reduced. The idea and the\neffectiveness of the circuits are validated by\nASIC measurements. The next steps are to\ncarry out in-vitro measurements and encapsulate\nthe ASIC for implantation experiments.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-88f703b elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"88f703b\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8cb78b9 exad-glass-effect-no exad-sticky-section-no\" data-id=\"8cb78b9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-23090d6 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-text-editor\" data-id=\"23090d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\tContact:<br>\n<strong>Dr. Zili Yu<\/strong><br>\nPhone: +49 711 21855\u00a0 325<br>\nE-Mail <a href=\"mailto:Ziliyu@ims-chips.de\">Ziliyu@ims-chips.de<\/a>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9f34c74 elementor-section-boxed elementor-section-height-default elementor-section-height-default exad-glass-effect-no exad-sticky-section-no\" data-id=\"9f34c74\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c9ceaec exad-glass-effect-no exad-sticky-section-no\" data-id=\"c9ceaec\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4445289 exad-sticky-section-no exad-glass-effect-no elementor-widget elementor-widget-spacer\" data-id=\"4445289\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>In the BMBF-funded PanaMEA project, an<br \/>\nASIC for a miniature pancreatic implant is<br \/>\ndeveloped at IMS CHIPS. A unique feature<br \/>\nof the design is an integrated solution<br \/>\nfor FOPP (Fraction of Plateau Phase)<br \/>\ndetection of the beta-cell activity. Smart<br \/>\napproach is adopted to keep the design<br \/>\noverhead to a minimum, resulting in a<br \/>\nlow-power system with highly reduced<br \/>\ndata volume, which can be applied to<br \/>\nmore advanced beta-cell activity monitoring.<\/p>\n","protected":false},"author":1,"featured_media":9799,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[14],"tags":[],"class_list":["post-9798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-newsletter-1-2022"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PanaMEA \u2013 ASIC for a Miniature Pancreatic Implant - Institut f\u00fcr Mikroelektronik Stuttgart<\/title>\n<meta name=\"description\" content=\"PanaMEA \u2013 ASIC fora Miniature PancreaticImplant\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ims-chips.com\/?p=9798\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PanaMEA \u2013 ASIC for a Miniature Pancreatic Implant - 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